Review
doi: 10.1016/0968-0004(91)90025-q.
News from the nucleolus: rRNA gene expression
Affiliations
- PMID: 1858134
- DOI: 10.1016/0968-0004(91)90025-q
Item in Clipboard
Review
News from the nucleolus: rRNA gene expression
Trends Biochem Sci.
1991 Feb.
Abstract
Although the typical, actively growing eukaryotic cell contains over 10,000 different transcripts, half of its RNA synthetic capacity is devoted to the production of a single kind of RNA. This is the pre-ribosomal RNA, which is synthesized in a special compartment of the nucleus, the nucleolus, and is the exclusive product of transcription by RNA polymerase I. In vivo and in vitro approaches have revealed the major features of rRNA gene transcription and of the subsequent processing of the primary transcript.
Similar articles
-
RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription.Biochem Biophys Res Commun. 2016 Sep 16;478(2):873-80. doi: 10.1016/j.bbrc.2016.08.044. Epub 2016 Aug 13. Biochem Biophys Res Commun. 2016. PMID: 27530925
-
The nucleolus and transcription of ribosomal genes.Biol Cell. 2004 Oct;96(8):579-94. doi: 10.1016/j.biolcel.2004.04.015. Biol Cell. 2004. PMID: 15519693 Review.
-
Does Saccharomyces need an organized nucleolus?Chromosoma. 1997 Jun;105(7-8):444-51. Chromosoma. 1997. PMID: 9211972
-
Loss of human ribosomal gene CpG methylation enhances cryptic RNA polymerase II transcription and disrupts ribosomal RNA processing.Mol Cell. 2009 Aug 28;35(4):414-25. doi: 10.1016/j.molcel.2009.07.008. Mol Cell. 2009. PMID: 19716787
-
The multifunctional nucleolus.Nat Rev Mol Cell Biol. 2007 Jul;8(7):574-85. doi: 10.1038/nrm2184. Nat Rev Mol Cell Biol. 2007. PMID: 17519961 Review.
Cited by
-
New data concerning the functional organization of the mammalian cell nucleolus: detection of RNA and rRNA by in situ molecular immunocytochemistry.Nucleic Acids Res. 1992 Dec 11;20(23):6195-200. doi: 10.1093/nar/20.23.6195. Nucleic Acids Res. 1992. PMID: 1282236 Free PMC article.
-
Different chromatin structures along the spacers flanking active and inactive Xenopus rRNA genes.Mol Cell Biol. 1992 Oct;12(10):4288-96. doi: 10.1128/mcb.12.10.4288-4296.1992. Mol Cell Biol. 1992. PMID: 1406621 Free PMC article.
-
Transcription-coupled repair in RNA polymerase I-transcribed genes of yeast.Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):649-54. doi: 10.1073/pnas.022373099. Epub 2002 Jan 8. Proc Natl Acad Sci U S A. 2002. PMID: 11782531 Free PMC article.
-
PARP promoter-mediated activation of a VSG expression site promoter in insect form Trypanosoma brucei.Nucleic Acids Res. 1995 Mar 25;23(6):1010-8. doi: 10.1093/nar/23.6.1010. Nucleic Acids Res. 1995. PMID: 7731788 Free PMC article.
-
Anatomy of the parp gene promoter of Trypanosoma brucei.EMBO J. 1991 Nov;10(11):3379-86. doi: 10.1002/j.1460-2075.1991.tb04902.x. EMBO J. 1991. PMID: 1840521 Free PMC article.