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. 2008 Jan-Mar;78(1):11-8.

[A method designed for the assessment of myocardial metabolism in rats with 18F-FDG using small-animal-PET. Initial experience in Mexico]

[Article in Spanish]
Erick Alexánderson Rosas  1 , Nayelli Ortega López, Rafael Ojeda Flores, Guillermo Mendoza Vázquez, Gloria Adame Ocampo, Aloha Meave González, Yolanda Saldaña Domínguez, Pedro A Lamothe Molina, Mónica Rodriguez Valero, Leonardo García Rojas Castillo, José Narro Robles
Affiliations
  • PMID: 18581709

[A method designed for the assessment of myocardial metabolism in rats with 18F-FDG using small-animal-PET. Initial experience in Mexico]

[Article in Spanish]
Erick Alexánderson Rosas et al. Arch Cardiol Mex. 2008 Jan-Mar.

Abstract

Purpose: To standarize an acquisition protocol for the study of myocardial metabolism in adult rats.

Material and methods: Three Wistar adult male rats were studied in three different protocols: no fasting group, fasting group over a period of 12 hr before the study with only water provided ad libitum, and fasting group by the same time receiving an oral 50% glucose solution. Thirty-minute acquisition images were obtained with a micro-PET, thirty and sixty minutes after the administration of 370-555 MBq 18F-FDG. Comparative and visual analysis were performed by two experts in the field.

Results: Eigtheen studies were analyzed, six per group. The best images were those of the first group, especially those taken at 60 minutes after the 18F-FDG administration.

Conclusion: It is possible to establish the non-fasting protocol for the assessment of myocardial metabolism to be used in the future for the myocardial viability evaluation in ischemic cardiopathy.

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