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Review
. 2008 Aug;20(4):207-12.
doi: 10.1016/j.smim.2008.05.002. Epub 2008 Jun 25.

T and B lymphocyte differentiation from hematopoietic stem cell

Anne Y Lai  1 , Motonari Kondo
Affiliations
Review

T and B lymphocyte differentiation from hematopoietic stem cell

Anne Y Lai et al. Semin Immunol. 2008 Aug.

Abstract

Until the past few years, it has been thought that lymphoid and myeloid lineage segregation represents the first step of lineage restriction during hematopoiesis from hematopoietic stem cell. Recent investigation of the cell populations within multipotent progenitors in the bone marrow has led to new understanding of how hematopoietic stem cells diversify into different hematopoietic cell types. This review focuses on the recent advances in understanding the developmental events that occur during hematopoietic stem cell specification into the T and B lymphocyte lineages in adult mice.

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Figures

Figure 1
Figure 1
The classical model of hematopoiesis predicts that the first step of lineage restriction from HSC is lymphoid and myeloid lineage commitment. In this model, CLP and CMP are symmetrically derived from the same MPP.
Figure 2
Figure 2
A revised version of the classical model of the hematopoietic tree. In this model, CLP and CMP are generated asymmetrically from different MPPs. Prior to lymphoid lineage commitment at the CLP stage, MPPs loses myeloid lineage differentiation potential in a step-wise fashion.
See this image and copyright information in PMC

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