Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2008;9(3):774-81.
doi: 10.1208/s12249-008-9113-1. Epub 2008 Jun 27.

A novel approach to optimize and formulate fast disintegrating tablets for nausea and vomiting

Honey Goel  1 , Nishant Vora, Vikas Rana
Affiliations
Comparative Study

A novel approach to optimize and formulate fast disintegrating tablets for nausea and vomiting

Honey Goel et al. AAPS PharmSciTech. 2008.

Abstract

The aim of this study was to optimize and formulate fast disintegrating tablets (FDTs) for nausea and vomiting using aminoacetic acid, carmellose and sodium alginate with enough mechanical strength. Ondansetron HCl (water soluble) or domperidone (water insoluble) drug were added to FDTs and their disintegration behaviour was evaluated. Plackett Burman Screening Design was used to screen the independent active process variables [concentration of aminoacetic acid (X (1)), concentration of carmellose (X (2)) and tablet crushing strength (X (3))] which were found to actively influence the dependent variables [disintegration time in the mouth (DT), wetting time (WT), and water absorption ratio (WAR)] for both the drugs. Also, the coefficients of active variables (DT, WT and WAR) of FDTs containing domperidone was found to be significantly different (P < 0.05) from the coefficients of active factors (X (1), X (2) and X (3)) containing ondansetron HCl FDTs. Further, FDTs containing domperidone was prepared according to central composite design for estimating the effect of active factors (X (1), X (2), X (3)) in extended spherical domain. The regression analysis of quadratic fit revealed that DT, WT and WAR were 98% correlated with active factors (X (1), X (2) or X (3)). The optimized domperidone FDTs were further compared with superdisintegrants (croscarmellose sodium or crospovidone). The data revealed that optimized domperidone FDTs were better than domperidone FDTs containing croscarmellose or crospovidone. Hence, this novel excipients combination can be used for delivery of water insoluble drugs in place of superdisintegrants.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
The coefficients associated with effect of various formulation and process variables on DT, WT, WAR of domperidone and ondansetron HCl
Fig. 2
Fig. 2
Relationship between DT and WT with tablet crushing strength of optimized FDTs (A 1) and FDTs containing crospovidone (F 2) and croscarmellose sodium (F 6)
Fig. 3
Fig. 3
In-vitro dissolution profiles of batches F 2, F 6, A 1
See this image and copyright information in PMC

References

    1. Chang R. K., Guo X., Burnside B. A., Couch R. A. Fast dissolving tablets. Pharm. Technol. 2000;24:52–59.
    1. Mallet L. Caring for the elderly patient. J. Am. Pharm. Assoc. 1996;36:628. - PubMed
    1. Seager H. Drug delivery products and the Zydis fast dissolving dosage. J. Pharm. Pharmacol. 1998;50:375–382. - PubMed
    1. Parakh S. R., Gothoskar A. V. A review of mouth dissolving technologies. Pharm. Technol. 2003;27:92–100.
    1. Schiemeir S., Schmidt P. C. Fast dispersible ibuprofen tablets. Eur. J. Pharm. Sci. 2002;15:295–305. doi: 10.1016/S0928-0987(02)00011-8. - DOI - PubMed

Publication types

MeSH terms