Early life trauma and sensitivity to current life stressors in individuals with and without cocaine dependence
- PMID: 18584568
- PMCID: PMC2692094
- DOI: 10.1080/00952990802122614
Early life trauma and sensitivity to current life stressors in individuals with and without cocaine dependence
Abstract
This study investigated the link between exposure to early life trauma, sensitivity to current daily stressors, and cocaine dependence. Individuals with (n = 105) or without (n = 53) cocaine dependence completed the Early Trauma Inventory and the Daily Hassles Scale. In comparison to controls, cocaine-dependent individuals reported almost twice as many daily hassles and perceived those hassles more negatively (p < .001). For participants with cocaine dependence, a significant relationship between exposure to early life trauma and negative perception of current daily hassles was observed (p < .01), whereas no such relationship was observed for participants without cocaine dependence. Adverse childhood events may lead to an altered view of the environment that contributes to increased irritability with daily life events among cocaine-dependent individuals.
Figures

References
-
- Kikusui T, Faccidomo S, Miczek KA. Repeated maternal separation: Differences in cocaine-induced behavioral sensitization in adult male and female mice. Psychopharmacology. 2005;178(2–3):202–210. - PubMed
-
- Levine S. Developmental determinants of sensitivity and resistance to stress. Psychoneuroendocrinology. 2005;30(10):939–946. - PubMed
-
- Lynch WJ, Mangini LD, Taylor JR. Neonatal isolation stress potentiates cocaine seeking behavior in adult male and female rats. Neuropsychopharmacology. 2005;30:322–329. - PubMed
-
- Rounsaville BJ, Weissman MM, Wilber CH, Kleber HD. Pathways to opiate addiction: an evaluation of differing antecedents. Br J Psychiatry. 1982;141:437–446. - PubMed
-
- Seeman M, Seeman AZ. Life strains, alienation, and drinking behavior. Alcohol Clin Exp Res. 1992;16(2):199–205. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical