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Randomized Controlled Trial
. 2008;34(4):441-7.
doi: 10.1080/00952990802082180.

The effects of levetiracetam on alcohol consumption in alcohol-dependent subjects: an open label study

Ofra Sarid-Segal  1 , Joanna Piechniczek-Buczek, Clifford Knapp, Maryam Afshar, Eric Devine, Laurie Sickles, Emma Uwodukunda, Courtney Richambault, Jillian Koplow, Domenic Ciraulo
Affiliations
Randomized Controlled Trial

The effects of levetiracetam on alcohol consumption in alcohol-dependent subjects: an open label study

Ofra Sarid-Segal et al. Am J Drug Alcohol Abuse. 2008.

Abstract

The aim of this open-label pilot study was to assess the efficacy and safety of the novel anticonvulsant agent, levetiracetam, for the treatment of alcohol dependence. A maximal dose of 2000 mg was administered daily for 10 weeks to alcohol dependent subjects (n = 20). Mean reported ethanol intake declined significantly from 5.3 to 1.7 standard drinks per day. Levetiracetam was well tolerated by most subjects.

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Figures

Figure 1
Figure 1
The mean (± S.E.) number of standard drinks consumed by evaluable subjects (n = 16) per day baseline period and treatment weeks 1 through 10. ∗Indicates p < 0.05 for comparison with baseline values.
See this image and copyright information in PMC

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