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Comment
. 2008 Jun 27;133(7):1133-5.
doi: 10.1016/j.cell.2008.06.008.

A lexicon for homeodomain-DNA recognition

Markus Affolter  1 , Matthew Slattery, Richard S Mann
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A lexicon for homeodomain-DNA recognition

Markus Affolter et al. Cell. .
Free article

Abstract

Decoding the cis-regulatory logic of eukaryotic genomes requires knowledge of the DNA-binding specificities of all transcription factors. New work (Berger et al., 2008; Noyes et al., 2008) provides individual specificities for nearly all Drosophila and mouse homeodomains, key DNA-binding domains in many transcription factors. The data underscore the complexity of determining target specificities in vivo.

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