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. 2008 Oct;49(10):4340-6.
doi: 10.1167/iovs.08-1749. Epub 2008 Jun 27.

The National Eye Institute Visual Function Questionnaire in the Macular Telangiectasia (MacTel) Project

Traci E Clemons  1 , Mark C Gillies, Emily Y Chew, Alan C Bird, Tunde Peto, Maria Figueroa, Molly W Harrington; Macular Telangiectasia Research Group
Collaborators, Affiliations

The National Eye Institute Visual Function Questionnaire in the Macular Telangiectasia (MacTel) Project

Traci E Clemons et al. Invest Ophthalmol Vis Sci. 2008 Oct.

Abstract

Purpose: To describe vision-targeted health-related quality of life (HR-QOL), measured with the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) in a cohort of patients with macular telangiectasia (MacTel) type 2 and to evaluate the relationship between visual acuity and NEI-VFQ-25 scores.

Methods: This was an analysis of cross-sectional baseline data from a longitudinal natural history study. Patients with MacTel type 2 were enrolled in the Natural History Study of The Macular Telangiectasia Project (The MacTel Project). NEI-VFQ-25 were completed at enrollment. Linear correlation and regression analyses were used to relate baseline NEI-VFQ-25 overall and subscale scores to visual acuity.

Results: Participants reported lower vision-related functioning measured by the NEI-VFQ-25 in most of the domains measured by the NEI VFQ compared with that of a normal reference group (P < 0.001 for all domains except color vision). Visual acuity was found to be associated with the NEI-VFQ-25 in many of the domains measuring degree of difficulty with common visual activities.

Conclusions: This is the first cross-sectional cohort study to assess vision targeted HR-QOL in patients with MacTel type 2. Patients with MacTel type 2 reported markedly reduced visual functioning compared to reports of a normal reference group. These findings provide support to the use of the NEI-VFQ-25 in patients with MacTel type 2 to measure the effect of disease and potential therapies on vision-targeted HR-QOL.

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Figures

Figure 1
Figure 1
Comparison of NEI-VFQ-25 Subscale Means (Reference group versus MacTel Cohort). * Two tailed t-test P < 0.0001.
See this image and copyright information in PMC

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