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. 2008 Aug;40(8):952-4.
doi: 10.1038/ng.164. Epub 2008 Jun 29.

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

Michal Pravenec  1 , Paul C Churchill, Monique C Churchill, Ondrej Viklicky, Ludmila Kazdova, Timothy J Aitman, Enrico Petretto, Norbert Hubner, Caroline A Wallace, Heike Zimdahl, Vaclav Zidek, Vladimir Landa, Joseph Dunbar, Anil Bidani, Karen Griffin, Nathan Qi, Martina Maxova, Vladimir Kren, Petr Mlejnek, Jiaming Wang, Theodore W Kurtz
Affiliations

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

Michal Pravenec et al. Nat Genet. 2008 Aug.

Abstract

To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.

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