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. 2008 Sep;52(9):3438-40.
doi: 10.1128/AAC.00452-08. Epub 2008 Jun 30.

Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins

Guangshun Wang  1 , Karen M Watson, Robert W Buckheit Jr
Affiliations

Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins

Guangshun Wang et al. Antimicrob Agents Chemother. 2008 Sep.

Abstract

From among 15 human cathelicidin LL-37-derived peptides, FK-13 was identified as the smallest peptide active against human immunodeficiency virus (HIV) and GI-20 had the highest therapeutic index, which was twice that of LL-37. BMAP-18, which is derived from bovine cathelicidin BMAP-27, possessed a therapeutic index similar to that of GI-20. Peptide sequence order, helical structures, and aromatic residues are important in HIV inhibition.

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