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Randomized Controlled Trial
. 2008 Oct;31(10):1949-54.
doi: 10.2337/dc07-2272. Epub 2008 Jun 30.

Reduced progression to type 2 diabetes from impaired glucose tolerance after a 2-day in-hospital diabetes educational program: the Joetsu Diabetes Prevention Trial

Tetsuya Kawahara  1 , Keiichi Takahashi, Tetsuya Inazu, Tadashi Arao, Chie Kawahara, Takahiro Tabata, Hiroyuki Moriyama, Yosuke Okada, Emiko Morita, Yoshiya Tanaka
Affiliations
Randomized Controlled Trial

Reduced progression to type 2 diabetes from impaired glucose tolerance after a 2-day in-hospital diabetes educational program: the Joetsu Diabetes Prevention Trial

Tetsuya Kawahara et al. Diabetes Care. 2008 Oct.

Abstract

Objective: We assessed the effects of a 2-day in-hospital diabetes educational program in preventing or delaying progression of impaired glucose tolerance (IGT) to type 2 diabetes, including analysis of changes in serum lipids, body weight, and blood pressure after the program.

Research design and methods: A total of 426 subjects (51 +/- 9 years, BMI 24.6 +/- 3.9 kg/m(2)) with newly diagnosed IGT were randomly assigned to three groups, 143 as the short-term hospitalization with diabetes education and support (STH) group, 141 as the nonhospitalization but diabetes education and support (DES) group, and 142 as the neither hospitalization nor education (control) group.

Results: The average follow-up was 3.1 years. The incidence of diabetes was 8.0, 10.7, and 13.2 cases per 100 person-years for STH, DES, and control groups, respectively. The incidence of diabetes was 42% lower (95% CI 33-51%) in the STH group and 27% lower (15-37%) in the DES group than in the control group. The incidence of diabetes was 21% lower (10-31%) in the STH group than in the DES group.

Conclusions: The 2-day in-hospital program with diabetes education and support every 3 months was more effective in preventing or delaying the progression from IGT to diabetes than only diabetes education and support every 3 months.

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Figures

Figure 1
Figure 1
Cumulative incidence of diabetes according to study group. The diagnosis of diabetes was based on the 2003 criteria of the American Diabetes Association. The incidence of diabetes differed significantly among the three groups (P < 0.01 for each comparison). Full line, STH group; dotted line, DES group; broken line, control group.
Figure 2
Figure 2
Change in fasting plasma glucose (A), 2-h OGTT plasma glucose (B), A1C (C), and body weight (D) according to study group. Each data point represents the mean ± SE of the participants of the specific groups examined at the indicated time. •, STH group; □, DES group; ▴, control group.
See this image and copyright information in PMC

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