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Comment
. 2008 Jul;10(7):757-9.
doi: 10.1038/ncb0708-757.

Breaking down EMT

Romain Levayer  1 , Thomas Lecuit
Affiliations
Comment

Breaking down EMT

Romain Levayer et al. Nat Cell Biol. 2008 Jul.

Abstract

Epithelial-mesenchymal transition, in which epithelial cells lose their polarity and become motile mesenchymal cells, occurs during development and marks a key step in tumour progression towards metastasis. Most studies of this process have focused on the disassembly of adherens junctions, but regulation of basement membrane breakdown by a pathway involving RhoA and microtubules may be equally important.

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