Leiomyosarcoma of the uterus metastatic to the brain: a case report

Abstract

Uterine leiomyosarcoma is a rare tumour with an aggressive growth pattern. The principle treatment is surgical excision by abdominal hysterectomy, however, the rate of recurrent disease is high. Radiotherapy and chemotherapy have limited impact on overall survival and the prognosis for those patients with recurrent disease is poor. Cerebral metastases are extremely uncommon with only 14 cases published in the literature. We report a further case who succumbed to systemic disease 2 months following successful excision of a solitary brain metastases. This case highlights the aggressive nature of the tumour and poor prognosis despite successful neurosurgical excision.