Mesp1 at the heart of mesoderm lineage specification
- PMID: 18593549
- DOI: 10.1016/j.stem.2008.06.017
Mesp1 at the heart of mesoderm lineage specification
Abstract
Stem cell-based cardiac regeneration requires a detailed understanding of the factors that induce cardiac lineage commitment. In this issue of Cell Stem Cell, Lindsley et al. (2008) and Bondue et al. (2008) use embryonic stem cells to identify a key role for Mesp1 in this process.
Comment on
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Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs.Cell Stem Cell. 2008 Jul 3;3(1):55-68. doi: 10.1016/j.stem.2008.04.004. Cell Stem Cell. 2008. PMID: 18593559 Free PMC article.
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Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification.Cell Stem Cell. 2008 Jul 3;3(1):69-84. doi: 10.1016/j.stem.2008.06.009. Cell Stem Cell. 2008. PMID: 18593560
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