The origins of blood: induction of hematopoietic stem cells from different sources
- PMID: 18593553
- DOI: 10.1016/j.stem.2008.06.008
The origins of blood: induction of hematopoietic stem cells from different sources
Abstract
Ex vivo hematopoiesis from embryonic sources offers exciting promises in basic research and medicine. In this issue of Cell Stem Cell, Ledran et al. (2008) describe human embryonic stem cell (hESC)-derived hematopoiesis, while Taoudi et al. (2008) define the origin of definitive hematopoietic stem cells (HSCs) from the mouse aorta-gonad-mesonephros (AGM) region.
Comment on
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Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches.Cell Stem Cell. 2008 Jul 3;3(1):85-98. doi: 10.1016/j.stem.2008.06.001. Cell Stem Cell. 2008. PMID: 18593561
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Extensive hematopoietic stem cell generation in the AGM region via maturation of VE-cadherin+CD45+ pre-definitive HSCs.Cell Stem Cell. 2008 Jul 3;3(1):99-108. doi: 10.1016/j.stem.2008.06.004. Cell Stem Cell. 2008. PMID: 18593562
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