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. 2008 Sep;46(9):3091-3.
doi: 10.1128/JCM.00712-08. Epub 2008 Jul 2.

VanB phenotype-vanA genotype Enterococcus faecium with heterogeneous expression of teicoplanin resistance

Il Joong Park  1 , Wee Gyo Lee, Jong Hee Shin, Kyung Won Lee, Gun Jo Woo
Affiliations

VanB phenotype-vanA genotype Enterococcus faecium with heterogeneous expression of teicoplanin resistance

Il Joong Park et al. J Clin Microbiol. 2008 Sep.

Abstract

Six VanB phenotype-vanA genotype isolates of Enterococcus faecium with heterogeneous expression of teicoplanin resistance which gave rise to an outbreak at a Korean tertiary care teaching hospital have IS1216V in the coding region of vanS. This could be the underlying cause of the VanB phenotype-vanA genotype with heterogeneous expression of teicoplanin resistance.

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Figures

FIG. 1.
FIG. 1.
Teicoplanin (TP) MIC determination by Etest of E. faecium AJJ5 with heterogeneous expression of teicoplanin resistance (A), a colony of E. faecium isolate AJJ5 grown in the inhibition zone next to the Etest strip (B), VanB phenotype-vanA genotype E. faecium JC03 without heterogeneous expression of teicoplanin resistance (C), and E. faecium BM4147 (D).
FIG. 2.
FIG. 2.
Effect of overnight growth in the presence of teicoplanin (6 μg/ml; TP6) on E. faecium AJJ5 with heterogeneous expression of teicoplanin resistance (A), VanB phenotype-vanA genotype E. faecium JC03 without heterogeneous expression of teicoplanin resistance (B), and E. faecium BM4147 (C) in the absence (0) or presence of teicoplanin. Teicoplanin concentration in the overnight culture/in the subculture medium. O.D., optical density.
See this image and copyright information in PMC

References

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