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Review
. 2008 Nov 18;26(49):6183-8.
doi: 10.1016/j.vaccine.2008.06.057. Epub 2008 Jul 1.

Vaccine immunogenetics: bedside to bench to population

Gregory A Poland  1 , Inna G Ovsyannikova, Robert M Jacobson
Affiliations
Review

Vaccine immunogenetics: bedside to bench to population

Gregory A Poland et al. Vaccine. .

Abstract

The immunogenetic basis for variations in immune response to vaccines in humans remains largely unknown. Many factors can contribute to the heterogeneity of vaccine-induced immune responses, including polymorphisms of immune response genes. It is important to identify those genes involved directly or indirectly in the generation of the immune response to vaccines. Our previous work with measles reveals the impact of immune response gene polymorphisms on measles vaccine-induced humoral and cellular immune responses. We demonstrate associations between genetic variations (single nucleotide polymorphisms, SNPs) in HLA class I and class II genes, cytokine, cell surface receptor, and toll-like receptor genes and variations in immune responses to measles vaccine. Such information may provide further understanding of genetic restrictions that influence the generation of protective immune responses to vaccines, and eventually the development of new vaccines.

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Comment in

  • "One-size fits all"?
    Tomljenovic L, Shaw CA. Tomljenovic L, et al. Vaccine. 2012 Mar 9;30(12):2040. doi: 10.1016/j.vaccine.2011.11.053. Epub 2011 Nov 23. Vaccine. 2012. PMID: 22119595 No abstract available.

References

    1. Centers for Disease Control and Prevention. Ten Great Public Health Achievements - United States, 1900–1999. MMWR. 1999 April;48(No 12):241–264. - PubMed
    1. CDC's 60th anniversary: director's perspective--William L. Roper, M.D., M.P.H., 1990–1993. MMWR Morb Mortal Wkly Rep. 2007;56(18):448–452. - PubMed
    1. Bunker JP, Frazier HS, Mosteller F. Improving health: measuring effects of medical care. Milbank Q. 1994;72(2):225–258. - PubMed
    1. Alper CA, Kruskall MS, Marcus-Bagley D, et al. Genetic prediction of nonresponse to hepatitis B vaccine. N.Engl.J.Med. 1989;321:708–712. - PubMed
    1. Poland GA, Ovsyannikova IG, Jacobson RM, Smith DI. Heterogeneity in vaccine immune response: The role of immunogenetics and the emerging field of vaccinomics. Clin.Pharmacol.Ther. 2007;82(6):653–664. - PubMed

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