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Comment
. 2008 Jul 8;14(1):5-7.
doi: 10.1016/j.ccr.2008.06.012.

Deregulating EMT and senescence: double impact by a single twist

Marjon A Smit  1 , Daniel S Peeper
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Free article
Comment

Deregulating EMT and senescence: double impact by a single twist

Marjon A Smit et al. Cancer Cell. .
Free article

Abstract

The acquisition of a fully malignant phenotype is limited by several barriers, including cellular senescence and the requirement to undergo an epithelial-mesenchymal transition (EMT). Deregulation of these processes is believed to occur by largely independent events. In this issue of Cancer Cell, Ansieau et al. (2008) challenge this view.

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