Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Jul 8;14(1):10-21.
doi: 10.1016/j.ccr.2008.06.001.

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

Francesca Bernassola  1 , Michael Karin, Aaron Ciechanover, Gerry Melino
Affiliations
Free article
Review

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

Francesca Bernassola et al. Cancer Cell. .
Free article

Abstract

The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources