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. 1991 Apr 26;547(1):171-4.
doi: 10.1016/0006-8993(91)90589-n.

Epidermal growth factor enhances short-term potentiation and facilitates induction of long-term potentiation in rat hippocampal slices

K Abe  1 , F J Xie, H Saito
Affiliations

Epidermal growth factor enhances short-term potentiation and facilitates induction of long-term potentiation in rat hippocampal slices

K Abe et al. Brain Res. .

Abstract

Effects of recombinant human epidermal growth factor (hEGF) on short-term potentiation (STP) of evoked potential were investigated in Schaffer/commissural-CA1 pyramidal cell synapses of rat hippocampal slices. Perfusion of hEGF (6-60 ng/ml) significantly enhanced the STP induced by shorter tetanus (11 impulses at 100 Hz) in a concentration-dependent manner and the effect resulted in generation of long-term potentiation (LTP). The results suggest that hEGF can activate the mechanisms related to induction of LTP.

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