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Clinical Trial
. 2008 Sep;102(3):287-92.
doi: 10.1016/j.ijgo.2008.04.014. Epub 2008 Jul 7.

Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis

Fabio Peixoto  1 , Aroldo Camargos, Geraldo Duarte, Iara Linhares, Luis Bahamondes, Alvaro Petracco
Affiliations
Clinical Trial

Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis

Fabio Peixoto et al. Int J Gynaecol Obstet. 2008 Sep.

Abstract

Objective: To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis.

Methods: Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment.

Results: Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7%, while the cure rates according to microscopy and Candida albicans culture were 81.8% and 73.9%, respectively. The cure rate for bacterial vaginosis was 75% and culture of Gardnerella vaginalis turned negative in 63.6% of cases following treatment. The medication was well tolerated.

Conclusion: Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis.

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