Leading Wnt down a PCP path: Cthrc1 acts as a coreceptor in the Wnt-PCP pathway
- PMID: 18606135
- DOI: 10.1016/j.devcel.2008.06.008
Leading Wnt down a PCP path: Cthrc1 acts as a coreceptor in the Wnt-PCP pathway
Abstract
Wnt signaling regulates many aspects of development through canonical and PCP signaling pathways. A paper by Yamamoto et al. in this issue of Developmental Cell identifies collagen triple helix repeat containing 1 as a Wnt-binding cofactor that specifically activates the Wnt-PCP pathway.
Comment on
-
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.Dev Cell. 2008 Jul;15(1):23-36. doi: 10.1016/j.devcel.2008.05.007. Dev Cell. 2008. PMID: 18606138
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources