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Comment
. 2008 Jul 15;112(2):444-5; author reply 445.
doi: 10.1182/blood-2008-02-140392.

Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease

Adam J Mead, Rosemary E Gale, Robert K Hills, Manu Gupta, Bryan D Young, Alan K Burnett, David C Linch
Comment

Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease

Adam J Mead et al. Blood. .
No abstract available

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References

    1. Whitman SP, et al. FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications. Blood. 2008;111:1552–1559. - PMC - PubMed
    1. Mead AJ. FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia. Blood. 2007;110:1262–1270. - PubMed
    1. Grundler R. FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model. Blood. 2005;105:4792–4799. - PubMed

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