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Comment
. 2008 Jul;26(7):769-70.
doi: 10.1038/nbt0708-769.

Hitting the mother lode of tumor angiogenesis

Daylon James, Sina Rabbany, Shahin Rafii
Comment

Hitting the mother lode of tumor angiogenesis

Daylon James et al. Nat Biotechnol. 2008 Jul.
No abstract available

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Figures

Figure 1
Figure 1
The structure of Lodamin enhances its bioavailability and stability in circulation and inhibits tumor growth and metastasis. Combining TNP-470 with a co-polymer generates Lodamin, an amphiphilic molecule that forms micelles in aqueous solution. Orally administered Lodamin shows rapid entry into circulation and maintains high levels in serum relative to free TNP-470. In mouse tumor models, Lodamin accumulates in tumor tissue and, by abrogating tumor vasculature, reduces primary tumor growth and liver metastasis.
See this image and copyright information in PMC

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