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Comment
. 2008 Jul 11;134(1):18-20.
doi: 10.1016/j.cell.2008.06.039.

Rab5 and rac team up in cell motility

Tobias Zech  1 , Laura Machesky
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Rab5 and rac team up in cell motility

Tobias Zech et al. Cell. .
Free article

Abstract

Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamidessi et al. (2008) show that Rab5-directed trafficking of Rac to the cell membrane is required for Rac-mediated actin assembly. Trafficking of Rac may influence the mode of cell migration during morphogenesis and cancer metastasis.

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