Dun1 counts on rad53 to be turned on
- PMID: 18614039
- DOI: 10.1016/j.molcel.2008.06.009
Dun1 counts on rad53 to be turned on
Abstract
In a recent issue of Molecular Cell, Lee et al. (2008) demonstrate that the forkhead-associated (FHA) domain of Dun1, a Chk2-related kinase involved in DNA damage signaling, selectively binds a diphosphorylated motif found in its paralog and upstream regulator Rad53.
Comment on
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Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.Mol Cell. 2008 Jun 20;30(6):767-78. doi: 10.1016/j.molcel.2008.05.013. Mol Cell. 2008. PMID: 18570878
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