Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Sep;9(6):570-4.
doi: 10.1038/gene.2008.52. Epub 2008 Jul 10.

HLA-DRB1*15 allele influences the later course of relapsing remitting multiple sclerosis

I Cournu-Rebeix  1 , E Génin, E Leray, M-C Babron, J Cohen, C Gout, M Alizadeh, H Perdry, G Semana, D Brassat, F Clerget-Darpoux, J Yaouanq, G Edan, M Rosenheim, B Fontaine
Affiliations

HLA-DRB1*15 allele influences the later course of relapsing remitting multiple sclerosis

I Cournu-Rebeix et al. Genes Immun. 2008 Sep.

Abstract

Most of the published works so far have aimed at finding genes associated with multiple sclerosis (MS) susceptibility. Very few studies have attempted to correlate disease features with DNA variants. In a well-characterized sample (651 patients) representative of multiple sclerosis natural history, we engaged a comprehensive study of the role of human leukocyte antigen (HLA) in the course of the disease. We investigated the role of HLA-DRB1*15 allele in samples stratified according to severity evaluated by the Multiple Sclerosis Severity Score (MSSS), time to reach EDSS 6.0 and disease type. We found that HLA-DRB1*15 genotype does not influence MS severity even among patients presenting with a given type of the disease. However, we show for the first time that HLA-DRB1*15 allele modulates the course of MS for relapsing-remitting (RR) onset patients likely by precipitating the secondary progressive (SP) phase.

PubMed Disclaimer

Publication types