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Review
. 2008 Dec;23(12):2131-46.
doi: 10.1007/s00467-008-0901-3. Epub 2008 Jul 10.

Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice

Xiaoyan Wang  1 , Van Anthony M Villar, Ines Armando, Gilbert M Eisner, Robin A Felder, Pedro A Jose
Affiliations
Review

Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice

Xiaoyan Wang et al. Pediatr Nephrol. 2008 Dec.

Abstract

Dopamine is important in the pathogenesis of hypertension because of abnormalities in receptor-mediated regulation of renal sodium transport. Dopamine receptors are classified into D(1)-like (D(1), D(5)) and D(2)-like (D(2), D(3), D(4)) subtypes, all of which are expressed in the kidney. Mice deficient in specific dopamine receptors have been generated to provide holistic assessment on the varying physiological roles of each receptor subtype. This review examines recent studies on these mutant mouse models and evaluates the impact of individual dopamine receptor subtypes on blood pressure regulation.

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Figures

Fig. 1
Fig. 1
Distribution of dopamine receptor subtypes (D1–5) and apical sodium transporters in rat tubules. PCT Proximal convoluted tubule, PST proximal straight tubule, TAL thick ascending limb of Henle’s loop, DCT distal convoluted tubule, CNT cortical connecting tubule, CCD cortical collecting duct, MCD medullar collecting duct, NHE3 sodium hydrogen exchanger type 3, NaPi2 sodium phosphate cotransporter type 2, NKCC2 sodium potassium two chloride cotransporter, NCC sodium chloride cotransporter, ENaC epithelial sodium channel
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