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Randomized Controlled Trial
. 2008 Jun;53(6):361-70.
doi: 10.1177/070674370805300605.

Personality and differential treatment response in major depression: a randomized controlled trial comparing cognitive-behavioural therapy and pharmacotherapy

R Michael Bagby  1 , Lena C Quilty, Zindel V Segal, Carolina C McBride, Sidney H Kennedy, Paul T Costa
Affiliations
Randomized Controlled Trial

Personality and differential treatment response in major depression: a randomized controlled trial comparing cognitive-behavioural therapy and pharmacotherapy

R Michael Bagby et al. Can J Psychiatry. 2008 Jun.

Abstract

Objective: Effective treatments for major depressive disorder exist, yet some patients fail to respond, or achieve only partial response. One approach to optimizing treatment success is to identify which patients are more likely to respond best to which treatments. The objective of this investigation was to determine if patient personality characteristics are predictive of response to either cognitive-behavioural therapy (CBT) or pharmacotherapy (PHT).

Method: Depressed patients completed the Revised NEO Personality Inventory, which measures the higher-order domain and lower-order facet traits of the Five-Factor Model of Personality, and were randomized to receive either CBT or PHT.

Result: Four personality traits--the higher-order domain neuroticism and 3 lower-order facet traits: trust, straightforwardness, and tendermindedness--were able to distinguish a differential response rate to CBT, compared with PHT.

Conclusion: The assessment of patient dimensional personality traits can assist in the selection and optimization of treatment response for depressed patients.

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Figures

Figure 1
Figure 1
Personality and treatment group interaction—FFM domain traits
Figure 2
Figure 2
Personality and treatment group interaction—FFM facet traits
Figure 3
Figure 3
Personality and treatment group interaction—FFM facet traits
Figure 4
Figure 4
Personality and treatment group interaction—FFM facet traits
See this image and copyright information in PMC

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