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. 2008 Nov;39(11):3079-82.
doi: 10.1161/STROKEAHA.108.519199. Epub 2008 Jul 10.

Prevalence and correlates of subclinical atherosclerosis in Alaska Eskimos: the GOCADAN study

Alexis Cutchins  1 , Mary J Roman, Richard B Devereux, Sven O E Ebbesson, Jason G Umans, Jianhui Zhu, Neil J Weissman, Barbara V Howard
Affiliations

Prevalence and correlates of subclinical atherosclerosis in Alaska Eskimos: the GOCADAN study

Alexis Cutchins et al. Stroke. 2008 Nov.

Abstract

Background and purpose: The recent increase in clinical cardiovascular disease in Alaska Eskimos suggests that changes in traditional lifestyle may have adverse public health consequences. This study examines the prevalence of subclinical vascular disease and its relation to risk factors in Alaska Eskimos.

Methods: Participants in the population-based Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study underwent evaluation of cardiovascular disease risk factors and carotid ultrasound. Outcome variables were carotid intimal-medial thickness and presence and extent of atherosclerosis.

Results: In multivariate analyses, intimal-medial thickness and presence and extent of atherosclerosis were all associated with traditional cardiovascular disease risk factors but not dietary intake of omega-3 fatty acids. Rates of carotid atherosclerosis were higher than those reported in 2 large population-based US studies.

Conclusions: Alaska Eskimos have similar traditional risk factors for carotid atherosclerosis as other ethnic and racial populations but have higher prevalences of atherosclerosis, possibly attributable to higher rates of smoking.

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Figures

Figure
Figure
Comparison of prevalences of carotid atherosclerosis in male (left) and female (right) participants in the GOCADAN Study, Atherosclerosis Risk in Communities Study, and Cardiovascular Health Study, subdivided according to 5-year age range. not significantly related to carotid ultrasound findings when added to the analyses.
See this image and copyright information in PMC

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