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. 2008 Oct;39(10):2876-9.
doi: 10.1161/STROKEAHA.107.513713. Epub 2008 Jul 10.

The association between kidney disease and cardiovascular risk in a multiethnic cohort: findings from the Northern Manhattan Study (NOMAS)

Thomas L Nickolas, Minesh Khatri, Bernadette Boden-Albala, Krzysztof Kiryluk, Xiaodong Luo, Palma Gervasi-Franklin, Myunghee Paik, Ralph L Sacco

The association between kidney disease and cardiovascular risk in a multiethnic cohort: findings from the Northern Manhattan Study (NOMAS)

Thomas L Nickolas et al. Stroke. 2008 Oct.

Abstract

Background and purpose: The objective of this study was to determine the relationship between chronic kidney disease (CKD), race-ethnicity, and vascular outcomes.

Methods: A prospective, multiracial cohort of 3298 stroke-free subjects with 6.5 years of mean follow-up time for vascular outcomes (stroke, myocardial infarction, vascular death) was used. Kidney function was estimated using serum creatinine and Cockcroft-Gault formula. Cox proportional hazards models were fitted to evaluate the relationship between kidney function and vascular outcomes.

Results: In multivariate analysis, Cockcroft-Gault formula between 15 and 59 mL/min was associated with a significant 43% increased stroke risk in the overall cohort. Blacks with Cockcroft-Gault formula between 15 and 59 mL/min had significantly increased risk of both stroke (hazard ratio, 2.65; 95% CI, 1.47 to 4.77) and combined vascular outcomes (hazard ratio, 1.59; 95% CI, 1.10-2.92).

Conclusions: Chronic kidney disease is a significant risk factor for stroke and combined vascular events, especially in blacks.

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Figures

Figure
Figure
Prevalence of kidney disease in the NOMAS cohort stratified by race-ethnicity and age.
See this image and copyright information in PMC

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