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. 2009 Apr 5;150B(3):381-8.
doi: 10.1002/ajmg.b.30824.

Genetic predictors of depressive symptoms in cardiac patients

Jeanne M McCaffery  1 , Qing Ling Duan, Nancy Frasure-Smith, Amina Barhdadi, Francois Lespérance, Pierre Théroux, Guy A Rouleau, Marie-Pierre Dubé
Affiliations

Genetic predictors of depressive symptoms in cardiac patients

Jeanne M McCaffery et al. Am J Med Genet B Neuropsychiatr Genet. .

Abstract

Numerous studies suggest that the prevalence of depression is greater among cardiac patients than in the general population. However, little attention has been paid to the possibility of genetic contributions to depressive symptoms in cardiac patients. We conducted a candidate gene study focusing on genes related to inflammation, platelet aggregation, endothelial function and omega-3 fatty acid metabolism as predictors of depressive symptoms among 977 participants with established cardiovascular disease. Results suggested that genetic variation related to endothelial dysfunction is predictive of depressive symptoms and that endothelial dysfunction may be a novel mechanism contributing to depressive symptoms among cardiac patients.

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Figures

Figure 1
Figure 1
Genetic association with Beck Depression Inventory – II scores among 977 cardiac patients, statistically adjusted for sex. VCAM1 – vascular cellular adhesion molecule 1 gene; CNR1 – cannabinoid receptor gene; CHRM2 – muscarinic2A receptor gene; CACNA1C – calcium channel, L-type, α1c subunit gene; VWF – von Willebrand factor gene; HTR2A – serotonin2A receptor gene.
See this image and copyright information in PMC

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