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Review
. 2008 Jul 7;7(6):18.
doi: 10.1186/jbiol79.

Stage debut for the elusive Drosophila insulin-like growth factor binding protein

Nazif Alic  1 , Linda Partridge
Affiliations
Review

Stage debut for the elusive Drosophila insulin-like growth factor binding protein

Nazif Alic et al. J Biol. .

Abstract

Insulin-like growth factor (IGF) binding proteins provide a layer of complexity to the insulin/IGF signaling system in mammals, but only now, in a recent study in Journal of Biology, has one such protein been functionally characterized in Drosophila.

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Figures

Figure 1
Figure 1
Sequence comparison of Imp-L2, its invertebrate homologs, and IGFBP-rP1. The sequences of Imp-L2 (Drosophila), Insulin-related peptide binding protein (IBP; S. frugiperda), ZIG-4 (C. elegans) and IGFBP-rP1 (human) were aligned using ClustalW2 [18]. Residues identical or similar in at least three sequences are highlighted in black and gray, respectively. Asterisks below the sequence show the cysteines thought to form two disulfide bridges. The two immunoglobulin-like domains are indicated by a gray bar and the region in IGFBP-rP1 that has the most similarity to IGFBPs by a black bar below the sequences. The annotation was adapted from [2,9].
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References

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