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Review
. 2008 Sep;213(1):10-7.
doi: 10.1016/j.expneurol.2008.05.016. Epub 2008 Jul 14.

Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on "Increased MCP-1 and microglia in various regions of human alcoholic brain"

Edith V Sullivan  1 , Natalie M Zahr
Affiliations
Review

Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on "Increased MCP-1 and microglia in various regions of human alcoholic brain"

Edith V Sullivan et al. Exp Neurol. 2008 Sep.
No abstract available

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Figures

Figure 1
Figure 1
a) Axial MR fluid attenuated inversion recovery (FLAIR) image of an acute a 35 year-old man with schizophrenia and acute nutritional deficiency-induced Wernicke's Encephalopathy (WE). Prominent are the hyperintense signals in the mammillary bodies and colliculi, indicative of inflammation in the acute phase of WE (taken from Sullivan and Pfefferbaum, 2008). b-c) Sagittal slice of b) an early-echo structural image and c) of a grand average post-pre difference image showing hyperintense areas in the thalamus and mammillary nuclei in pyrithiamine-treated rats (taken from Pfefferbaum, et al., 2007). d-e) T1-weighted SPoiled GRadient echo (SPGR) MR images of 53 year old man with a history of Wernicke's Encephalopathy, which developed into Korsakoff's Syndrome (KS). Note the shrunken mammillary bodies (arrows), indicative of necrosis, in the man with KS compared with the 59 year old healthy, nonalcoholic control man (taken from Sullivan and Pfefferbaum, 2008).
See this image and copyright information in PMC

Comment on

References

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