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. 1975 Dec;34(2):385-8.
doi: 10.1016/0014-2999(75)90268-x.

Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine

K Starke, E Borowski, T Endo

Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine

K Starke et al. Eur J Pharmacol. 1975 Dec.

Abstract

Strips of the rabbit main pulmonary artery were preincubated with 3H-noradrenaline. 3 X 10(-8) -- 10(6) M yohimbine enhanced the overflow of tritium and the smooth muscle contraction induced by transmural sympathetic nerve stimulation. The increase of the stimulation-evoked overflow of tritium was prevented by a high concentration of oxymetazoline. The results indicate that yohimbine is more potent in blocking the presynaptic than the postsynaptic alpha-adrenoceptors of the artery.

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