Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Oct;31(10):2006-12.
doi: 10.2337/dc08-0659. Epub 2008 Jul 15.

Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications

Maria F Lopes-Virella  1 , Rickey E Carter, Gregory E Gilbert, Richard L Klein, Miran Jaffa, Alicia J Jenkins, Timothy J Lyons, W Timothy Garvey, Gabriel Virella; Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications Cohort Study Group
Affiliations

Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications

Maria F Lopes-Virella et al. Diabetes Care. 2008 Oct.

Abstract

Objective: Because endothelial cell dysfunction and inflammation are key contributors to the development of complications in type 1 diabetes, we studied risk factors related to endothelial dysfunction and inflammation (C-reactive protein and fibrinogen, soluble vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and E-selectin, and fibrinolytic markers) in a subgroup of patients from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) study cohort.

Research design and methods: We determined which of these risk factors or clusters thereof are associated with the presence of and subsequent development of nephropathy and macrovascular complications (reflected by carotid intima-media thickness [IMT]).

Results: After adjustment for conventional risk factors (age, sex, DCCT treatment group, diabetes duration, A1C, systolic blood pressure, waist-to-hip ratio, total and HDL cholesterol, and smoking status), fibrinogen remained strongly associated with progression of internal and common carotid IMT (P < 0.01) and soluble E-selectin had a strong association with nephropathy (P < 0.01).

Conclusions: The best predictor for IMT progression in the DCCT/EDIC cohort was plasma fibrinogen, and the levels of soluble E-selectin discriminate patients with albuminuria better than conventional risk factors.

PubMed Disclaimer

References

    1. Tsimikas S, Willerson J, Ridker P: C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol 47:C19–C31, 2006 - PubMed
    1. Lopes-Virella MF, Virella G: Diabetes and atherosclerosis. In Contemporary Cardiology: Diabetes and Cardiovascular Disease, 2nd ed. Johnstone MT, Veves A, Eds. Totowa, NJ, Humana Press, 2006, p. 225–228
    1. Targher G, Zenari L, Bertolini L, Falezza G, Muggeo M, Zoppini G: Plasma total homocysteine levels are associated with von Willebrand factor, soluble intercellular adhesion molecule-1, and soluble tumor necrosis factor-α receptors in young type 1 diabetic patients without clinical evidence of macrovascular complications. Diabetes Care 24:1496–1497, 2001 - PubMed
    1. Targher G, Zenari L, Bertolini L, Muggeo M, Zoppini G: Elevated levels of interleukin-6 in young adults with type 1 diabetes without clinical evidence of microvascular and macrovascular complications. Diabetes Care 24:956–957, 2001 - PubMed
    1. Schram MT, Chaturvedi N, Schalkwijk C, Giorgino F, Ebeling P, Fuller JH, Stehouwer CD: Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetes Care 26:2165–2173, 2003 - PubMed

Publication types

MeSH terms