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. 2004;5(2):123-7.
doi: 10.1002/cfg.382.

Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse

Vicky Tsipouri  1 , John A Curtin, Pat M Nolan, Lucie Vizor, Claire A Parsons, Colin M Clapham, Ian D Latham, Lesley J Rooke, Jo E Martin, Jo Peters, A Jackie Hunter, Derek Rogers, Sohaila Rastan, Steve D M Brown, Elizabeth M C Fisher, Nigel K Spurr, Ian C Gray
Affiliations

Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse

Vicky Tsipouri et al. Comp Funct Genomics. 2004.

Abstract

Three mutant mice with pigmentation phenotypes were recovered from a genomewide random mouse chemical mutagenesis study. White toes (Whto; MGI:1861986), Belly spot and white toes (Bswt; MGI:2152776) and Dark footpads 2 (Dfp2; MGI:1861991) were identified following visual inspection of progeny from a male exposed to the point mutagen ethylnitrosourea (ENU). In order to rapidly localize the causative mutations, genome-wide linkage scans were performed on pooled DNA samples from backcross animals for each mutant line. Whto was mapped to proximal mouse chromosome (Mmu) 7 between Cen (the centromere) and D7Mit112 (8.0 cM from the centromere), Bswt was mapped to centric Mmul between D1Mit214 (32.1 cM) and D1Mit480 (32.8 cM) and Dfp2 was mapped to proximalMmu4 between Cen and D4Mit18 (5.2 cM). Whto, Bswt and Dfp2 may provide novel starting points in furthering the elucidation of genetic and biochemical pathways relevant to pigmentation and associated biological processes.

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References

    1. Anat Embryol (Berl). 1989;180(5):457-64 - PubMed
    1. Hum Mol Genet. 2000 Jul 22;9(12):1865-71 - PubMed
    1. Genes Dev. 2003 Jan 15;17(2):214-28 - PubMed
    1. Nat Genet. 2000 Aug;25(4):440-3 - PubMed
    1. Annu Rev Genomics Hum Genet. 2001;2:463-92 - PubMed