ROS eliminate danger
- PMID: 18631448
- DOI: 10.1016/j.immuni.2008.06.006
ROS eliminate danger
Abstract
Necrotic cells release HMGB1 as a danger signal to activate the immune system. In this issue of Immunity, Kazama et al. (2008) identify a mechanism that determines whether HMGB1 is tolerogenic or immunogenic.
Comment on
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Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein.Immunity. 2008 Jul 18;29(1):21-32. doi: 10.1016/j.immuni.2008.05.013. Immunity. 2008. PMID: 18631454 Free PMC article.
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