Comment
doi: 10.1016/j.immuni.2008.06.005.
With a little help from their friends: interleukin-21, T cells, and B cells
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- PMID: 18631451
- DOI: 10.1016/j.immuni.2008.06.005
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With a little help from their friends: interleukin-21, T cells, and B cells
Immunity.
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Free article
Abstract
T follicular cells help B cells generate high-affinity antibodies. Two papers in this issue of Immunity (Nurieva et al., 2008, and Vogelzang et al., 2008) have identified a role for interleukin-21 in the development of these specialized cells and highlight questions about how this dedicated population is generated.
Comment on
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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.Immunity. 2008 Jul 18;29(1):138-49. doi: 10.1016/j.immuni.2008.05.009. Epub 2008 Jul 3. Immunity. 2008. PMID: 18599325 Free PMC article.
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A fundamental role for interleukin-21 in the generation of T follicular helper cells.Immunity. 2008 Jul 18;29(1):127-37. doi: 10.1016/j.immuni.2008.06.001. Epub 2008 Jul 3. Immunity. 2008. PMID: 18602282
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