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Review
. 2008 Sep;55(3):345-52.
doi: 10.1016/j.neuropharm.2008.05.027. Epub 2008 Jun 3.

Ischemic stroke and neurogenesis in the subventricular zone

Rui Lan Zhang  1 , Zheng Gang Zhang, Michael Chopp
Affiliations
Review

Ischemic stroke and neurogenesis in the subventricular zone

Rui Lan Zhang et al. Neuropharmacology. 2008 Sep.

Abstract

The subventricular zone (SVZ) of the lateral ventricle contains neural stem and progenitor cells that generate neuroblasts, which migrate to the olfactory bulb where they differentiate into interneurons. Ischemic stroke induces neurogenesis in the SVZ and these cells migrate to the boundary of the ischemic lesion. This article reviews current data on cytokinetics, signaling pathways and vascular niche that are involved in processes of proliferation, differentiation, and migration of neural progenitor cells after stroke.

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Figures

Figure 1
Figure 1
Neurogenesis in the non-ischemic and ischemic SVZ of adult rodent brain. Depictions of sagittal (E and F) and coronal (B) views of rat brain in the SVZ which contains types A, B, and C cells (A). Schematic coronal view of neural stem/progenitor cells ( formula image in C and D) and neuroblasts ( formula image in C and D) in the SVZ of the right lateral ventricle of non-ischemic (C) and ischemic (D) hemispheres as well as a corresponding view of neuroblasts identified by doublecortin (DCX) positive cells (C′ and D′, green). Neuroblasts in the SVZ (C and C′ green) migrate through the rostral migratory stream (RMS, E and F, green color) into the olfactory bulb (OB, E and F, green color). However, after stroke, many neuroblasts in the SVZ migrate towards the ischemic striatum (D and D′, green color). Red color in panel F is GFAP positive astrocytes. CC = corpus callosum and DG = dentate gyrus.
Figure 2
Figure 2
The Notch signaling pathway. When ligands including Delta-like and Jagged families from signaling cells bind to Notch receptor in signaling receiving cells, NICD is cleaved by the γ-secretase enzyme complex. The NICD translocates into the nucleus and associates with CBF1 and others to activate target genes including Hes family members.
Figure 3
Figure 3
The Shh signaling pathway. In the absence of Sonic hedgehog (Shh), Patched 1 (Ptc1) represses the activation of Smoothened (Smo) and the downstream transduction cascade (Inactivation). Binding of Shh to the Ptc 1 activates Smo and this complex regulates Gli activity in nucleus.
See this image and copyright information in PMC

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