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Review
. 2008 Jul 15;68(14):5505-7.
doi: 10.1158/0008-5472.CAN-07-6348.

Cell competition and its possible relation to cancer

Nicholas E Baker  1 , Wei Li
Affiliations
Review

Cell competition and its possible relation to cancer

Nicholas E Baker et al. Cancer Res. .

Abstract

Cell competition can occur when cells of different genotypes share the same developing compartment, with one genotype displacing the other as a result of a proliferative advantage. Studies of cell competition in Drosophila have identified an active process of cell assassination and corpse engulfment, and also roles for Myc and the Warts/Hippo tumor suppressor pathway. Here, we discuss the possible relevance of cell competition to cancer.

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