Comment on

• Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.

  Eger EI 2nd, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM. Eger EI 2nd, et al. Anesth Analg. 2008 Aug;107(2):479-85. doi: 10.1213/01.ane.0000295805.70887.65. Anesth Analg. 2008. PMID: 18633026
• General anesthetics have additive actions on three ligand gated ion channels.

  Jenkins A, Lobo IA, Gong D, Trudell JR, Solt K, Harris RA, Eger EI 2nd. Jenkins A, et al. Anesth Analg. 2008 Aug;107(2):486-93. doi: 10.1213/ane.0b013e31817b70c1. Anesth Analg. 2008. PMID: 18633027 Free PMC article.
• Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility.

  Hendrickx JF, Eger EI 2nd, Sonner JM, Shafer SL. Hendrickx JF, et al. Anesth Analg. 2008 Aug;107(2):494-506. doi: 10.1213/ane.0b013e31817b859e. Anesth Analg. 2008. PMID: 18633028 Review.
• Additivity versus synergy: a theoretical analysis of implications for anesthetic mechanisms.

  Shafer SL, Hendrickx JF, Flood P, Sonner J, Eger EI 2nd. Shafer SL, et al. Anesth Analg. 2008 Aug;107(2):507-24. doi: 10.1213/ane.0b013e31817b7140. Anesth Analg. 2008. PMID: 18633029