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. 2008 Jul;107(1):167-70.
doi: 10.1213/ane.0b013e3181732dc2.

The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study

Shinji Akada  1 , Shinhiro Takeda, Yuko Yoshida, Keiko Nakazato, Masaki Mori, Takashi Hongo, Keiji Tanaka, Atsuhiro Sakamoto
Affiliations

The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study

Shinji Akada et al. Anesth Analg. 2008 Jul.

Abstract

Background: Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV.

Methods: This was a prospective clinical investigation in an intensive care unit. Dexmedetomidine was infused in 10 patients in whom NIV was difficult because of agitation.

Results: Ramsay and Richmond Agitation-Sedation Scale scores were maintained at 2.94 +/- 0.94 and -1.23 +/- 1.30, respectively. All patients were successfully weaned from NIV, and the respiratory state was not worsened.

Conclusion: This study shows that dexmedetomidine is an effective sedative drug for patients with NIV.

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