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Review
. 2008 Sep;144(3):287-94.
doi: 10.1093/jb/mvn090. Epub 2008 Jul 17.

Biosynthesis, remodelling and functions of mammalian GPI-anchored proteins: recent progress

Taroh Kinoshita  1 , Morihisa Fujita, Yusuke Maeda
Affiliations
Review

Biosynthesis, remodelling and functions of mammalian GPI-anchored proteins: recent progress

Taroh Kinoshita et al. J Biochem. 2008 Sep.

Abstract

More than 100 mammalian proteins are post-translationally modified by glycosylphosphatidylinositol (GPI) at their C-termini and are anchored to the cell surface membrane via the lipid portion. GPI-anchored proteins (GPI-APs) have various functions, such as hydrolytic enzymes, receptors, adhesion molecules, complement regulatory proteins and other immunologically important proteins. GPI-anchored proteins are mainly associated with membrane microdomains or membrane rafts enriched in sphingolipids and cholesterol. It is thought that association with membrane rafts is important for GPI-APs in signal transduction and other functions. Here, we review recent progress in studies on biosynthesis, remodelling and functions of mammalian GPI-APs.

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