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Editorial
. 2008 Jul 18;103(2):128-30.
doi: 10.1161/CIRCRESAHA.108.180604.

Therapeutic vasculogenesis: it takes two

Francesco Loffredo, Richard T Lee
Editorial

Therapeutic vasculogenesis: it takes two

Francesco Loffredo et al. Circ Res. .
No abstract available

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Figures

Figure 1
Figure 1. Coimplantation of human Mesenchymal Progenitor Cells and Endothelial Progenitor Cells induces in vivo vascularization of a tissue construct
During embryogenesis, angioblasts differentiate into Endothelial Cells and organize to form the primordial capillary-like structures. Mesenchymal Stem Cells differentiate into pericytes assuming positions surrounding the endothelial cells in the newly formed vessels. Pericytes regulate maturation and stabilization of the vascular network. Melero-Martin and colleagues reproduced vasculogenesis in a tissue construct using Matrigel as the scaffold. Cord blood-derived Endothelial Progenitor Cells or adult blood Endothelial Progenitor Cells where co-implanted with either bone marrow-derived or cord blood derived Mesenchymal Progenitor Cells to produce a stable and mature vascular network when implanted in vivo. The vascular structures where composed of human Endothelial Progenitor Cells surrounded by α-smooth muscle actin positive mesenchymal cells anastomosed with host vessels.
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References

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