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Comment
. 2008 Sep;105(3):779-81.
doi: 10.1152/japplphysiol.90889.2008. Epub 2008 Jul 17.

The best medicine: exercise training normalizes chemosensitivity and sympathoexcitation in heart failure

Michael K Stickland  1 , Jordan D Miller
Affiliations
Comment

The best medicine: exercise training normalizes chemosensitivity and sympathoexcitation in heart failure

Michael K Stickland et al. J Appl Physiol (1985). 2008 Sep.
No abstract available

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Figures

Fig. 1.
Fig. 1.
Exercise training-induced modulation of nitric oxide (NO) bioavailability, and angiotensin II (ANG II) in chronic heart failure (CHF). CHF is characterized by decreased NO bioavailability, increased oxidative stress, and increased ANG II. Although the work by Li et al. (3), in this month's issue of the Journal of Applied Physiology focuses on the carotid chemoreceptor, previous work has demonstrated that similar pathways may be activated in the brain stem and other cardiovascular sensory regions and may contribute to excessive sympathoexcitation in CHF. Li et al. demonstrate that exercise training increased neuronal NO, while reducing ANG II concentration at the carotid body, thereby reducing the carotid chemoreflex and sympathoexcitation in CHF. NOS, NO synthase; eNOS, endothelial NOS; nNOS, neuronal NOS; SOD, superoxide dismutase; AT1R, angiotensin type I receptor; NTS, nucleus tractus solitarii.
See this image and copyright information in PMC

Comment on

References

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