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. 2008 Sep 15:201-202:163-5.
doi: 10.1016/j.jneuroim.2008.01.018. Epub 2008 Jul 21.

ZIC antibodies in paraneoplastic cerebellar degeneration and small cell lung cancer

Lidia Sabater  1 , Luis Bataller, Marc Suárez-Calvet, Albert Saiz, Josep Dalmau, Francesc Graus
Affiliations

ZIC antibodies in paraneoplastic cerebellar degeneration and small cell lung cancer

Lidia Sabater et al. J Neuroimmunol. .

Abstract

Patients with isolated ZIC4 antibodies usually have paraneoplastic cerebellar degeneration (PCD) and small cell lung cancer (SCLC) but the frequency is unknown. We analyzed the presence of ZIC1, ZIC2 and ZIC4 antibodies in 27 patients with PCD and SCLC negative for other onconeural antibodies. ZIC antibodies were detected in nitrocellulose filters with phage plaques. Four (15%) PCD sera recognized ZIC2. Three of these positive sera also reacted with ZIC1 and two with ZIC4. Our study suggests that 1) the incidence of isolated ZIC antibodies is low in PCD patients and SCLC and 2) ZIC antibodies are probably directed to epitopes shared by the three ZIC proteins.

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Figures

Fig. 1
Fig. 1
Detection of ZIC antibodies with phage plaques (see Materials and methods). The four quadrants contained A) ZIC4, B) ZIC1, C) ZIC2, and D) irrelevant phages that were immunoreacted with a positive serum that recognized the three ZIC proteins. Note that immunoreactivity was much stronger with the ZIC2 phage.
See this image and copyright information in PMC

References

    1. Antoine JC, Absi L, Honnorat J, Boulesteix J, de Brouker T, Vial C, Butler M, De Camilli P, Michel D. Antiamphiphysin antibodies are associated with various paraneoplastic syndromes and tumors. Arch. Neurol. 1999;56:172–177. - PubMed
    1. Aruga J, Yokota N, Hashimoto M, Furuichi T, Fukuda M, Mikoshiba K. A novel zinc finger protein, ZIC, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J. Neurochem. 1994;63:1880–1890. - PubMed
    1. Aruga J, Minowa O, Yaginuma H, Kuno J, Nagai T, Noda T, Mikoshiba K. Mouse Zic1 is involved in cerebellar development. J. Neurosci. 1998;18:284–293. - PMC - PubMed
    1. Bataller L, Wade DF, Fuller GN, Rosenfeld MR, Dalmau J. Cerebellar degeneration and autoimmunity to zinc-finger proteins of the cerebellum. Neurology. 2002;59:1985–1987. - PubMed
    1. Bataller L, Wade DF, Graus F, Rosenfeld MR, Dalmau J. The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction. Ann. Neurol. 2003;53:123–127. - PubMed

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