Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Dec;66(12):1910-2.
doi: 10.1016/j.apradiso.2008.06.004. Epub 2008 Jun 11.

A convenient route to [68Ga]Ga-MAA for use as a particulate PET perfusion tracer

Carla J Mathias  1 , Mark A Green
Affiliations

A convenient route to [68Ga]Ga-MAA for use as a particulate PET perfusion tracer

Carla J Mathias et al. Appl Radiat Isot. 2008 Dec.

Abstract

A convenient method is described for compounding [(68)Ga]Ga-MAA (MAA=macroaggregated human serum albumin) with the eluate of a commercially available TiO(2)-based (68)Ge/(68)Ga generator. The final [(68)Ga]Ga-MAA product was obtained with an 81.6+/-5.3% decay-corrected radiochemical yield and a radiochemical purity of 99.8+/-0.1% (n=5). Microscopic examination showed the [(68)Ga]Ga-MAA product to remain within the original particle size range. The entire procedure, from generator elution to delivery of the final [(68)Ga]Ga-MAA suspension, could be completed in 25 min. Only 4.4+/-0.9% of the total (68)Ge breakthrough remaining associated with the final [(68)Ga]Ga-MAA product. The procedure allows reasonably convenient preparation of [(68)Ga]Ga-MAA in a fashion that can be readily adapted to sterile product compounding for human use.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Representative samples of the MAA particles before (left) and after (right) labeling with 68Ga. The smallest squares of the hemacytometer are □50-micrometers on a side. The 68Ga-labeled MAA particles remain within the specifications for the Pulmolite® kit (i.e., >90% of the particles between 10 and 90 micrometers, with typical average size of 15 to 30 micrometers and none >150 micrometers).
See this image and copyright information in PMC

References

    1. Bergmann SR, Fox KAA, Rand AL, McElvany KD, Welch MJ, Markham J, Sobel BE. Quantification of region myocardial blood flow in vivo with H2O. Circulation. 1984;70:724–733. - PubMed
    1. Browne E, Firestone RB. In: Table of Radioactive Isotopes. Shirley VS, editor. New York: Wiley; 1986. pp. 68–72.
    1. Chester DA, Hales C, Hnatowich DJ, Hoop B. Three-dimensional reconstruction of lung perfusion image with positron detection. J. Nucl. Med. 1975;16:80–82. - PubMed
    1. Davis MA. Particulate radiopharmaceuticals for pulmonary studies. In: Subramanian G, Rhodes BA, Cooper JF, Sodd VJ, editors. Radiopharmaceuticals. New York: Soc. Nucl. Med.; 1975. pp. 267–281.
    1. Even GA, Green MA. Gallium-68-labeled macroaggregated human serum albumin, 68Ga-MAA. Nucl. Med. Biol. 1989;16:319–321. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources