Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Oct;17(10):1391-7.
doi: 10.1007/s00586-008-0722-x. Epub 2008 Jul 19.

SAPHO syndrome associated spondylitis

Tomoyuki Takigawa  1 , Masato Tanaka, Kazuo Nakanishi, Haruo Misawa, Yoshihisa Sugimoto, Tomohiro Takahata, Hiroyuki Nakahara, Shinnosuke Nakahara, Toshifumi Ozaki
Affiliations

SAPHO syndrome associated spondylitis

Tomoyuki Takigawa et al. Eur Spine J. 2008 Oct.

Abstract

The concept of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome has been well clarified, after Chamot et al. suggested this peculiar disorder in 1987. The most commonly affected site in SAPHO syndrome is the anterior chest, followed by the spine. However, the clinical course and taxonomic concept of SAPHO spinal lesions are poorly understood. This study was performed to analyze: (1) the detailed clinical course of spinal lesions in SAPHO syndrome, and (2) the relationship between SAPHO syndrome with spinal lesions and seronegative spondyloarthropathy. Thirteen patients with spondylitis in SAPHO syndrome were analyzed. The features of spinal lesions were a chronic onset with a slight inflammatory reaction, and slowly progressing non-marginal syndesmophytes at multi spinal levels, besides the coexistence of specific skin lesions. SAPHO syndrome, especially spinal lesions related to palmoplantar pustulosis, can be recognized as a subtype of seronegative spondyloarthropathy.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Case 2. A 42-year-old woman had a past history of receiving antibiotics due to unidentified spondylitis at 29 years old. There was no particular symptom afterwards. At the age of 42, lower back and nape pain with low-grade fever appeared. Simultaneously, a cutaneous lesion (PPP) appeared for the first time. a, b Cervical MRI showing consecutive multi-level lesions from C2–C7. c, d Lumbar MRI showing an abnormal intensity of L1/2 and L2/3 discs as well as L1 and L2 vertebrae
Fig. 2
Fig. 2
Case 3. A 50-year-old woman had marked lumbago since the age of 45 years old, showing repeated remission and exacerbation. a, b Plain radiographs showing ivory vertebrae and non-marginal syndesmophyte
Fig. 3
Fig. 3
Case 9. A 39-year-old man had suffered from intractable palmar (a) and plantar (b) pustulosis since 35 years old. He sometimes felt nape and anterior chest pain from 37 years old, and hypesthesia of his left upper extremity at 39 years old
Fig. 4
Fig. 4
Case 6. A-67-year-old woman experienced nape and back pain with low-grade fever. She developed PPP and sometimes felt anterior chest pain from 57 years old. a, b AP and PA views, respectively. Bony scintigraphy (99mTc-MDP) shows an abnormally high uptake of the bilateral sternocostoclavicular joint and C4, C7, and T8
See this image and copyright information in PMC

References

    1. Amital H, Applbaum YH, Aamar S, Daniel N, Rubinow A. SAPHO syndrome treated with pamidronate: an open-label study of 10 patients. Rheumatology (Oxford) 2004;43:658–661. doi: 10.1093/rheumatology/keh149. - DOI - PubMed
    1. Amor B, Dougados M, Mijiyawa M. Criteria of the classification of spondylarthropathies. Rev Rhum Mal Osteoartic. 1990;57:85–89. - PubMed
    1. Ashurst PJ. Relapsing pustular eruptions of the hands and feet. Br J Dermatol. 1964;76:169–180. doi: 10.1111/j.1365-2133.1964.tb14502.x. - DOI - PubMed
    1. Chamot AM, Benhamou CL, Kahn MF, Beraneck L, Kaplan G, Prost A. Acne-pustulosis-hyperostosis-osteitis syndrome. Results of a national survey. 85 cases. Rev Rhum Mal Osteoartic. 1987;54:187–196. - PubMed
    1. Court C, Charlez C, Molina V, Clerc D, Miquel A, Nordin JY. Isolated thoracic spine lesion: is this the presentation of a SAPHO syndrome? A case report. Eur Spine J. 2005;14:711–715. doi: 10.1007/s00586-004-0791-4. - DOI - PMC - PubMed

LinkOut - more resources