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Review
. 2007:(2):159-81.

Nucleophilic carbenes as organocatalysts

F Glorius  1 , K Hirano
Affiliations
  • PMID: 18642525
Review

Nucleophilic carbenes as organocatalysts

F Glorius et al. Ernst Schering Found Symp Proc. 2007.

Abstract

N-Heterocyclic carbenes (NHC) have become an important class of organocatalysts and class of ligands for transition-metal catalysis. In organocatalyzed umpolung reactions, thiazolium salt-derived NHC have been used successfully for decades. Even so, during recent years there has been an increased interest in NHC-catalyzed transformations and many new reactions have been developed. This article focuses on the use of NHC in the conjugate umpolung of alpha,beta-unsaturated aldehydes.

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